Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

First, a precursor mRNA (pre-mRNA) is formed that contains both coding information for the protein (exons) as well as non-coding segments (introns). The introns need to be cut out of the pre-mRNA ...

First, a precursor mRNA (pre-mRNA) is formed that contains both coding information for the protein (exons) as well as non-coding segments (introns). The introns need to be cut out of the pre-mRNA in ...

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

The introns need to be cut out of the pre-mRNA in the cell nucleus and the exons reconnected at the interfaces. This process is known as splicing. Ultimately, the spliced messenger RNA consists of ...

In the case of retained introns without decoy exons or cassette exons (top and middle), we suggest ... One μg of total RNA was used for polyA-RNA isolation and library preparation using the KAPA mRNA ...

They found that mRNA-based COVID-19-vaccinations cause a significant and persistent change through acetylation, i.e., the binding of a chemical group to specific, immunologically relevant genes of ...

Researchers at the University of Cologne and University Hospital Cologne have shown in their study that the novel mRNA-based COVID-19 vaccines not only induce acquired immune responses such as ...