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To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...
Additionally, it dramatically increased antibody titer by up to 128-fold in vivo, compared to the codon-optimization benchmark mRNA sequence H.
Alltrna is advancing a new class of genetic medicines based on the power of tRNA biology to universally treat Stop Codon Disease, which encompasses thousands of genetic diseases caused by a ...
A more effective vaccine technology may be on the horizon. In a new study in mice, researchers from the University of ...
The team then redesigned mRNA sequences to avoid these ‘off-target’ effects, by correcting the error-prone genetic sequences in the synthetic mRNA. This produced the intended protein.” At issue is a ...
mRNA display is an entire in vitro selection method that takes advantage of cell-free translation systems for the generation of polypeptide sequences. Both the expression and the selection are ...
A research team from The University of Osaka and the Institute of Science Tokyo has developed a class of mRNA medicines that ...