Previous UV cross‐linking studies demonstrated that, upon integration of the U2 snRNP into the spliceosome, a 14 kDa protein (p14) interacts directly with the branch adenosine, the nucleophile for the ...

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Researchers in the Galej Group at EMBL Grenoble have provided new insights into the structure of the minor spliceosome, an essential RNA-protein complex Structure of U11 snRNP, one of the subunits of ...

The minor spliceosome has a similar architecture, but its main building blocks are different (U11, U12, U4atac, U6atac, and U5 snRNPs). How exactly these blocks assemble to build the minor spliceosome ...

Researchers have revealed the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process.

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process.

In this new study, the researchers reveal the structure of U11 snRNP -- one of the five subunits of the minor spliceosome, which initiates the intron selection process.

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

An open and important question is whether proteins serve analogous functions in the spliceosome (see the review by Collins and Guthrie 17 in this issue) and perhaps other reactions in the cell.