T.b. gambiense is responsible for causing African sleeping sickness in humans, leading to severe symptoms including fever, headaches, extreme fatigue, and aching muscles and joints, which do not ...

Using an innovative in vitro model of the blood-brain barrier, Dennis Grab of Johns Hopkins University and his colleagues found that Trypanosoma brucei gambiense requires calcium ions and cysteine ...

Humans resist infection by the African parasite Trypanosoma brucei owing to the trypanolytic activity of the serum apolipoprotein L1 (APOL1). Following uptake by endocytosis in the parasite, APOL1 ...

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei. PLoS Pathogens , 2014; 10 (5): e1004130 DOI: 10.1371/journal.ppat.1004130 Cite This Page : ...

More information: Mechanism of Trypanosoma brucei gambiense resistance to human serum, Nature (2013) DOI: 10.1038/nature12516 Abstract The African parasite Trypanosoma brucei gambiense accounts ...

Alpha-difluoromethylornithine – while effective for treating Trypanosoma brucei gambiense, this compound requires a more complex and meticulous treatment plan and is therefore seldom used.

Health experts are warning of a potentially fatal but little-known disease called human African trypanosomiasis (HAT) - also ...

Source Reference: Betu Kumeso VK, et al "Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single ...

There are 2 forms of the disease: one caused by Trypanosoma brucei gambiense, found in 24 countries in West and Central Africa, accounting for more than 92% of cases.

Two distinct kinetoplastid flagellates can cause human African trypanosomiasis: Trypanosoma brucei var. gambiense and Trypanosoma brucei var. rhodesiense, which are both subspecies of Trypanosoma ...