Before protein synthesis can proceed, noncoding regions (introns) of mRNA must be removed and the coding regions (exons) joined together. Sign up for C&EN's must-read weekly newsletter Email Address * ...

If pseudo splice sites are used instead of the correct splice sites during protein synthesis, the resulting mRNA will contain the wrong instructions – cryptic splicing – that could alter ...

Protein synthesis in nerve cell dendrites underlies long-term memory formation in the brain, among other functions. Knowing how proteins are made to order at the synapse can help researchers ...

Protein splicing is a naturally occurring post‐translational process in which inteins, as self‐excising protein segments, precisely remove themselves from a host polypeptide and concomitantly ...

Although we have long known that this signal strongly inhibits protein synthesis in general, during hemoglobin gene expression it first plays its indispensable, positive role before being turned ...

When the genetic code is transcribed into RNA for protein synthesis, alternative splicing can lead to the production of different transcripts from the same gene, depending on the selected genetic ...

William Fairbrother and colleagues use a massively parallel splicing assay (MaPSy) to analyze 4,964 exonic, disease-causing mutations for splicing defects in vivo and in vitro. They find that 10% ...

At the same time, noncoding RNAs act as enzymes, scaffolds, and regulatory molecules, contributing greatly to the regulation of gene activity, RNA splicing, protein synthesis, and even DNA ...

For many protein-coding genes, the lab notes, alternative splicing regulates the production of multiple isoforms. Splicing requires >200 proteins and five snRNAs that assemble into a ...