Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

Learn how cell-free protein synthesis helps researchers overcome the challenges of traditional membrane protein production ...

A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel ...

Barcelona-based genetic medicines company SpliceBio has raised $135 million in a series B round to back its novel protein-splicing drug delivery system, the biotech announced Wednesday. The money will ...

While the metabolic effects of serine starvation have been extensively investigated, our goal is to better understand how serine starvation affects protein synthesis and expression. We found that ...

We observed the same splicing switch if de novo protein synthesis was inhibited by the presence of cycloheximide (Fig. 1E; Appendix Fig. S 1C). These experiments show a fast and transient splicing ...

1 Introduction Inteins have become powerful tools in synthetic biology, biotechnology, and biochemistry. These proteins were discovered by Bowman et al. (1988), and the mechanism of intein trans ...

The team also discovered that in the absence of hnRNPM, cryptic splicing can form double stranded RNA (dsRNA), which is known to trigger interferon immune responses. "Tumors with low hnRNPM show ...