During the first step of converting genetic information into functional proteins, cells transcribe the double-stranded helix ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Parse Biosciences today announced their commitment to support researchers from the Icahn School of Medicine at Mount Sinai in gen ...

The ”What This Means” segment is now available here.

Following CRISPR-Cas9 treatment, RNA-Seq can be performed to assess the impact of the modifications on splicing patterns and validate the desired changes. Modulating Splicing Factors and RNA-Seq ...

Much as ChatGPT generates poetry, a new A.I. system devises blueprints for microscopic mechanisms that can edit your DNA. The physical structure of OpenCRISPR-1, a gene editor created by A.I ...

The fundamental mechanism of splicing has been studied with model pre-mRNAs including 158- and 231-nt introns, for historical instance, that are spliced very efficiently in vitro and in vivo.

Alternative splicing is a molecular mechanism that modifies pre-mRNA constructs prior to translation . This process can produce a diversity of mRNAs from a single gene by arranging coding sequences ...

Nagoya University. "Tracing mechanisms of large exon splicing during vertebrate evolution." ScienceDaily. ScienceDaily, 20 November 2021. <www.sciencedaily.com / releases / 2021 / 11 ...

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, have recently identified the mechanism behind regulated splicing ...