Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

In addition, mutations in splicing factors and U snRNAs are also linked to many human cancers and affect the splicing of many mRNAs. Our group recently discovered that one of the components of the ...

“I wasn't surprised by the result.” Call it the Joao Factor. Fonseca only fed that frenzy in his press conference. “When I arrived here, my first goal was to qualify for the main draw,” he ...

Mechanisms like upstream open reading frames and alternative splicing contribute to these inconsistencies. Many paradoxical genes modulate the tumor immune microenvironment, exerting tumor-suppressive ...

aMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain. bUniversidad de Córdoba, Córdoba, Spain. cReina Sofia University Hospital, Córdoba, Spain. dCIBER Fisiopatología de ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

This important study addresses how 3' splice site choice is modulated by the conserved spliceosome-associated protein Fyv6. The authors provide compelling evidence Fyv6 functions to enable selection ...

the spliceosome helps cells to interpret and select genes which lead to essential protein production. Photo by National Cancer Institute on Unsplash Errors in this process, known as splicing ...