These circular RNAs are generated when the pre-mRNA splicing machinery “backsplices ... SR proteins, core spliceosome, and transcription termination factors that control the outputs of reporter and ...

Conditional knockout studies and transcriptomic analyses have identified key transcription factors governing cochlear ... Mutations affecting the core splicing machinery can also cause disease. Since ...

In addition, mutations in splicing factors and U snRNAs are also linked to many human cancers and affect the splicing of many mRNAs. Our group recently discovered that one of the components of the ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

Splicing is a basic requirement for producing proteins that fulfill an organism’s vital functions. Faulty functioning of a spliceosome can lead to a variety of serious diseases. Researchers at ...