RBP splicing factors are sequence-specific ... The fit between a splice site and the spliceosome components that bind it influences splicing activity. Strong splice sites closely match consensus ...

"The spliceosome is composed of multiple components ... Some highly aggressive tumors produce large amounts of USP39 and related splicing factors, likely due to their high division rate.

The process of RNA splicing by the spliceosome helps to generate molecular diversity beyond the genome sequence. In the May 3 Science, Tyson Clark and colleagues at the University of California, Santa ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read “snurps”) – and about 150 proteins, involved in different stages of the ...

The results of this work reveal how an alternative splicing mechanism regulates an essential factor for neuronal identity.

The spliceosome is composed of multiple components ... aggressive tumors generate high levels of USP39 and associated splicing factors: They need extremely accurate splicing, which USP39 performs ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Rgenta Therapeutics, a clinical-stage biotechnology company pioneering the development of a new class of oral small molecules ...

Varvara Dikaya's research sheds light on an essential part of this puzzle: RNA splicing, a process that ... this protein is part of the spliceosome, a molecular complex that modifies RNA before ...

Widespread alterations in RNA processing (splicing, polyadenylation ... such as the transcription factor c-MYC and spliceosome mutations, confer vulnerabilities across multiple levels of RNA ...