A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically ...

The disruption causes a protein imbalance that can result in mis-splicing of multiple genes involved in brain function, and may explain why some of the social and behavioral outcomes of ASD ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

JOURNAL NAME: American Journal of Molecular Biology, Vol.15 No.1, January 24, 2025 ABSTRACT: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proprotein convertase (PCs) family ...

Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with greater ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

RNA splicing defects are emerging molecular hallmarks of cancer. The gene encoding splicing factor RNA binding motif protein 10 (RBM10) has been found frequently mutated in various types of cancer, ...

Splicing factors are emerging as important regulators of B cell biology, especially in activated B cells, with the consequent impact on the germinal center reaction (Qureshi et al, 2023; ...

By identifying shared splicing neoantigens present in up to 90% of cancer patients, SNAF presents new therapeutic targets and expands understanding of cancer biology ...

Discovered in the 1970s, the mechanisms of RNA splicing have been well characterized through numerous studies in eukaryotic and prokaryotic systems. In this article, we describe the mechanisms of ...