Cells use editing tools to skip or rearrange information stored in DNA. Thanks to a 10-million-euro ERC Synergy Grant co-financed by ERC and UKRI, researchers have today launched a new project to ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.

Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts ...

Q: What role does alternative splicing play in molecular biology? Alternative splicing greatly expands the diversity of the proteins that can be made from a single gene.

Discovered in the 1970s, the mechanisms of RNA splicing have been well characterized through numerous studies in eukaryotic and prokaryotic systems. In this article, we describe the mechanisms of ...

Q: What role does alternative splicing play in molecular biology? Alternative splicing greatly expands the diversity of the proteins that can be made from a single gene.

Mutated Cohesin Throws DNA Splicing out of Whack, Resulting in Cancer Cohesin mutations cause dysregulations in alternative splicing, contributing to tumor initiation and progression, a study finds.

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...