For many eukaryotic introns, splicing is done in a series of reactions which are catalyzed by the spliceosome, ... Here, authors engineer a universal guide RNA scaffold from the U7 snRNA, ...

Using single-nuclei RNA sequencing (snRNA-seq), scientists from Mass General Brigham, SUNY Upstate Medical University, and elsewhere have identified specific brain cell types in the hippocampus ...

A new study found that aged neurons have defects in key proteins that make them vulnerable to molecular stress and neurodegenerative damage.

Our finding that the spliceosome deposits a multi‐protein complex 20‐‐24 nt upstream of exon–exon junctions on multiple mRNAs was unexpected. ... Lewis J, Gamberi C, Jarmolowski A, McGuigan C and ...

ConspectusIntron removal from premature-mRNA (pre-mRNA splicing) is an essential part of gene expression and regulation that is required for the production of mature, protein-coding mRNA. The ...