The spliceosome, which forms on introns, is composed of proteins and noncoding RNAs called small nuclear RNAs (snRNAs). In ...

Furthermore, the U5 snRNA–exon 1 interaction was detected in the presence of EDTA, which allows spliceosome assembly but blocks both catalytic steps 25 (Supplementary Fig. 2). U5 snRNA has been ...

The spliceosome, which forms on introns, ... In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5’ splice site at the beginning of the intron.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

The cutting tools of the spliceosome's snRNA are brought into position, but first in an inactive form; they are packed into other components of the spliceosome, rather like a knife that is ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

Shematic representation of the role of snRNA in alternative splicing. snRNA U1 and U2 are responsible for identifying the 5’ and 3’ end of the region to ... that some of the basal components may have ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron. Until now, ...

The spliceosome, which forms on introns, ... In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron.