The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

Heidelberg University. "Spliceosome: How cells avoid errors when manufacturing mRNA." ScienceDaily. ScienceDaily, 7 February 2025. <www.sciencedaily.com / releases / 2025 / 02 / 250207122612.htm>.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, but until now, the specific roles of its numerous components were not ...

The research article, titled "Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome," represents a significant advancement in understanding the ...

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes – more than nine in ten ...

First Spliceosome Blueprint Reveals Complex Interplay, Uncovers Drug Targets October 31, 2024 ...

The spliceosome and Group II introns are believed to share a common ancestor that was responsible for spreading introns throughout the genome, but while Group II introns can splice themselves out of ...

Wan Ruixue is a researcher and a supervisor of Ph.D. students with the School of Life Sciences at Westlake University, in East China's Zhejiang Province. She has made important contributions to ...

Wan Ruixue is a researcher and a supervisor of Ph.D. students with the School of Life Sciences at Westlake University, in East China's Zhejiang Province. She has made important contributions to ...