In this study, the researchers reveal the structure of U11 snRNP—one of the five subunits of the minor spliceosome, which initiates the intron selection process.

Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome’s catalytic centre. Here we report the cryo-electron microscopy ...

Researchers have revealed the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process.

"The largely stable structure of the spliceosome center enabled us to obtain high-resolution information. This means that a ...

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout the splicing process. Think of the spliceosome as an old ...

In this new study, the researchers reveal the structure of U11 snRNP -- one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

"By employing nuclear magnetic resonance (NMR) spectroscopy at the Bavarian NMR Center in Garching, we were able to elucidate the spatial structure of RBM5-OCRE in complex with SmN (a protein present ...

Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications. ... Researchers have revealed the ...

Think of the spliceosome as an old Transformers robot — it has individual pieces that operate independently but can also come together to form a larger structure. Sometimes, ...