In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Researchers have revealed the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process.

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

“The largely stable structure of the spliceosome center enabled us to obtain high-resolution information. This means that a spliceosome discarded during cellular quality control can be ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...