Bland et al. show that cancer types with heterozygous somatic hotspot mutations in the spliceosome component SF3B1 are vulnerable to PARP inhibition, which causes a defective response to ...

Synopsis Disrupting the expression of the minor spliceosome component RNPC3 reduces the growth of oncogene-driven cancer cells in a broad spectrum of tumours. Targeting the minor spliceosome may ...

Ten Indian American scientists were honored for their outstanding contributions in cancer research by the (SAASCR).

Important links exist between the process of pre-mRNA splicing and cancer, as illustrated by the frequent mutation of splicing factors in tumors and the emergence of various families of antitumor ...

NB in the high-E2F group presented increased activity in the spliceosome, ATP-dependent chromatin remodeling, and other pathways related to genome regulation (Figures 7A, B). To analyze the tumor ...

Biomolecules, 2019, 9, 633. (4) Molecular dynamics simulations of the spliceosome Bact complex show that selected carcinogenic isoforms undermine intron binding and/or alter the functional dynamics of ...

ScRNA-seq combined with ATAC-seq analysis to explore the metabolic balance mechanism of CCl4-induced liver inflammatory injury ...