Silencing NOTCH1 and SF3B1 using chitosan lactate nanoparticles (CL-NPs) loaded with small interfering RNAs (siRNAs) significantly enhanced efficacy of paclitaxel in chronic lymphocytic leukemia (CLL) ...

Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which ...

Interestingly, the large majority of the hits were splicing associated factors and/or components of the spliceosome. The latter was surprising because loss of core spliceosome factors would be ...