Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer.

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukemia and breast cancer.

What’s the spliceosome and why does it matter in cancer? SF3B1 is a principal component of a piece of cellular machinery called the spliceosome. The spliceosome is critical to a fundamental biological ...

A number of compounds, derived from bacterial fermentation products, have been found to target subunits of the spliceosome and display anticancer properties. In this Review, Valcárcel and ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer. It is also a target for anti-cancer ...

The team began by investigating how the levels of non-mutated SF3B1, a core spliceosome component, contribute to the MDS disease.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

The spliceosome is the molecular machine in our cells that puts the blueprints for proteins into a readable form. Researchers at the Max Planck Institute (MPI) for Multidisciplinary Sciences in ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer.