For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer.

The Galej Group at EMBL Grenoble has published new structural insights into minor spliceosome function in the journal Molecular Cell.

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

This process is catalyzed by the spliceosome in which combination of small nuclear ribonucleoproteins (U1, U2, U4, U5, U6) forms a spliceosome. The SF3B1 protein is a core component of the U2 snRNP ...

Background About half of MDS patients carry genetic alterations, also known as somatic mutations, in the spliceosome genes, with SF3B1 being the most common one.

SF3B1 mutations occurred more frequently in de novo myelodysplastic syndromes than therapy-related myelodysplastic syndrome, according to results of a phase 2 study presented at Society of ...