Like the spliceosome, the ribosome undergoes conformational changes to perform chemical catalysis. Such conformational dynamics can often be an impediment to understanding structure and function.

Poxvirus alters host ribosome function to prioritize viral protein synthesis, inducing structural changes in the 40S subunit and utilizing factors such as RACK1 and eIF3.

Massively Parallel Ribosome Profiling (MPRP) enables rapid identification of viral proteins without the need to grow live viruses. genprowebdirectory Facebook Linkedin RSS Twitter Youtube ...

The eukaryotic cell emerged as an evolutionary algorithmic phase transition Eukaryogenesis happened abruptly, led by the tension of increasing gene length and the constraints on producing longer ...

Exactly how poxviruses hijack their host's ribosomes, however, has not been well understood, said Derek Walsh, Ph.D., professor of Microbiology-Immunology, who was senior author of the study.

Our finding that the spliceosome deposits a multi‐protein complex 20‐‐24 nt upstream of exon–exon junctions on multiple mRNAs was unexpected. ... the involvement of cytoplasmic ribosomes in ...

ConspectusIntron removal from premature-mRNA (pre-mRNA splicing) is an essential part of gene expression and regulation that is required for the production of mature, protein-coding mRNA. The ...