A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps ...

"The spliceosome is composed of multiple components that secure production of functional proteins controlling cellular life," explains Đikić. "If this complex is disrupted, it can lead to the ...

Feb. 2, 2024 — A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules that orchestrate the RNA editing process, but until now, the specific roles of its numerous components were ...

Precursor messenger RNA is edited into its final form by an RNA–protein assembly called the spliceosome. Structural evidence provides insights into how the spliceosome is disassembled when its ...

It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout the splicing process. Think of the spliceosome as an old ...

"The focus of our interest was the protein RBM5, which often exhibits mutations in lung tumors," said Dr. André Mourão of the STB. "RBM5 helps to bring the spliceosome to the mRNA by binding to a ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

To sustain life, processes in biological cells have to be strictly controlled both in time and in space. Research workers at the Max Planck Institute for Biophysical Chemistry in Göttingen and ...

“When problems arise before the initial cut, the two proteins rush to the spliceosome to aid as quality controllers,” explains postdoc Dr Paulina Fisher. If the pre-mRNA is defective, GPATCH1 ...