Summary Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

Defining where to start cutting out the introns is just the first step in the spliceosome's complex assembly pathway. At least a dozen other steps are needed before the splicing reaction concludes.

Defining where to start cutting out the introns is just the first step in the spliceosome's complex assembly pathway. At least a dozen other steps are needed before the splicing reaction concludes.

Minor spliceosome has evolved to use additional non-canonical base-pairing interactions to fulfil this goal with high fidelity.” Defining where to start cutting out the introns is just the first step ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, but until now, the specific roles of its numerous components were not ...

Precursor messenger RNA is edited into its final form by an RNA–protein assembly called the spliceosome. Structural evidence provides insights into how the spliceosome is disassembled when its ...

As expected from the results of the functional annotation and the circadian pathway analysis, the acrophases of the 24-h cycling spliceosome components and splicing regulators showed a phase shift ...

Spliceosome malfunction causes neurodevelopmental disorders with overlapping features. Journal of Clinical Investigation, 2023; DOI: 10.1172/JCI171235 ...

They discovered that malfunctions in the spliceosome, a protein complex responsible for gene splicing, are a key factor in these disorders. This research paves the way for potential therapeutic ...

Clusters 2 were involved in five potential pathways, including base excision repair, cell cycle, nucleotide excision repair, RNA degradation, and spliceosome pathways (Figure 5D). Figure 4 (A), ...

Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor ...