Proper splicing requires efficient spliceosome assembly ... which modulates MYC pathway activity through ANKRD10-2’s function as a transcriptional coactivator.

We characterized back-splicing cis- and trans-elements, and found viral circRNAs resistant to spliceosome perturbation and lacking canonical splice donor-acceptors. Subsequent loss-of-function studies ...

By studying PORCUPINE’s role in the spliceosome, Dikaya and her team discovered that it influences multiple genetic pathways. Some of these pathways control how plants sense and react to cold ...

The "Poverty, Prosperity, and Planet. Pathways Out of the Polycrisis" report evaluates progress towards these goals. It offers the first global assessment of poverty and shared prosperity ...

Certain signals are generated by the overlap of multiple waves, such as in the so-called mTOR signaling pathway—a key regulator ... function of the so-called spliceosome complex, a key ...

This review highlights the key physiological functions of the TDP-43 protein, while considering an expanding spectrum of neurodegenerative diseases associated with pathogenic TDP-43 deposition, and ...

We're living through a big moment in spaceflight history. With the launch of Intuitive Machines' Athena spacecraft atop a SpaceX Falcon 9 rocket last night (Feb. 27), three lunar landers are ...

This month's cover highlights the article Natural variations of adolescent neurogenesis and anxiety predict the hierarchical status of adult inbred mice by Nicolas Toni, Thomas Larrieu and colleagues.

Metabolomics revealed that Mediator kinase inhibition altered core metabolic pathways in cell type-specific ways, and broad up-regulation of anti-inflammatory lipid mediators occurred specifically in ...

GENETIC researchers in Barcelona have reached a historic milestone, creating the very first map of the spliceosome. A key part of interpreting DNA, the spliceosome helps cells to interpret and ...

After, double strand is separated by helicases and create the mature miRNA; on the contrary, in non-canonical pathways, miRNA located within of mirtrons and are associated with spliceosome-dependent ...