The eukaryotic cell emerged as an evolutionary algorithmic phase transition Eukaryogenesis happened abruptly, led by the tension of increasing gene length and the constraints on producing longer ...

News & Views Published: December 2008 Short-circuiting RNA splicing Matthew D Disney Nature Chemical Biology 4, 723–724 (2008) Cite this article ...

Structural biology is the study of the molecular structure and dynamics of biological macromolecules, particularly proteins and nucleic acids, and how alterations in their structures affect their ...

Top of the list is PRMT5/MTA inhibitor MRTX1719, which BMS said could be a first-in-class therapy for cancers with MTAP deletions seen in around 10% of all cancers, including NSCLC, as well as ...

Following after is P-500, a selective, brain-penetrant PRMT5 inhibitor for advanced solid tumours, including high-grade glioma and uveal melanoma, that Pathos AI acquired from Prelude Therapeutics ...

Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. have divulged protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of ...

Upper panel (left to right) Dr. Mani Menon, Dr. Mahendra Bhandari, Dr. Rajvir Dahiya (President SAASRC); Dr, Dharam Paul Chauhan (Secretary SAASCR); Dr. Badrinath R. Konety, and Dr. Ravindra ...

The DExH‐box NTPase/helicase Prp22p plays two important roles in pre‐mRNA splicing. It promotes the second transesterification reaction and then catalyzes the ATP‐dependent release of mature mRNA from ...

NB in the high-E2F group presented increased activity in the spliceosome, ATP-dependent chromatin remodeling, and other pathways related to genome regulation (Figures 7A, B). To analyze the tumor ...

Notably, the overexpression of basic helix-loop-helix family member e22 (BHLHE22) recruits protein arginase methyltransferase 5 (PRMT5) to enhance colony stimulating factor 2 (CSF2) expression, result ...