Spliceosome-mediated RNA trans-splicing (SMaRT) is an emerging technology in which RNA pre-therapeutic molecules (PTMs) are designed to recode a specific pre-mRNA by suppressing cis-splicing while ...

Tau-mediated RNA splicing errors linked to Alzheimer’s. Graciela Gutierrez. 713-798-4710. Houston, TX - Oct 8, 2019. Share this article. ... Minor perturbations in the assembly and/or function of the ...

Conventional gene therapy of hemophilia A relies on the transfer of factor VIII (FVIII; encoded by the F8 gene) cDNA. We carried out spliceosome-mediated RNA trans-splicing (SMaRT) to repair ...

Spliceosome-mediated RNA trans-splicing (SMaRT) -- gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a ...

More information: Yi Li et al, Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates, Cell Research (2025). DOI: 10.1038/s41422-025-01084-w ...

Tau-mediated RNA splicing errors linked to Alzheimer's disease. Baylor College of Medicine. Journal Cell Reports DOI 10.1016/j.celrep.2019.08.104 ...

Spliceosome-mediated RNA trans-splicing (SMaRT) - gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice ...

Spliceosome-mediated RNA trans-splicing (SMaRT) - gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice site ...

“We report transcriptome-wide analyses upon systematic knock down of 305 spliceosome components and regulators in human cancer cells and the reconstruction of functional splicing factor networks ...

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

RNA splicing is a cellular process that is critical for gene expression. ... involving LUC7 proteins that influence spliceosome targeting of specific 5' splice sites.