Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

They succeeded once they were able to isolate the splicing complexes of the fungus that were in the midst of quality control ...

Proper splicing requires efficient spliceosome assembly ... a key component of nonsense-mediated mRNA decay (NMD), during cellular senescence and its impact on NMD efficiency, leading to the ...

Heidelberg biochemists and structural biologists from Shanghai decode the work of two control factors in mRNA splicing Two molecular control factors play a decisive role in what is known as splicing, ...

by interrupting alternative splicing. This was achieved by deleting the initial GU dinucleotide sequence at the 5’ end of the intron, which is required for the binding of the U1 protein of the ...

While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which is subsequently disassembled and made available for a new round of splicing. Two molecular control ...