Scientists are urgently seeking fluid biomarkers for frontotemporal dementia, the most common dementing illness among 40- and ...

The accuracy and efficiency of the spliceosome are often compromised in many human cancers. Mutations in the DNA can lead to RNA molecules that the spliceosome can no longer accurately recognise or ...

2020). Mutations affecting the core splicing machinery can also cause disease. Since core spliceosome components are, by definition, required constitutively in every cell, their disruption usually ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

Structural biologists provide a first-time look at the atomic level into the quality control mechanism of this complex molecular machine A complex molecular machine, the spliceosome, ensures that ...

In real life, mutants can arise when their DNA changes to give them an advantage over the rest of the population. A team from the University of Michigan has used simulations on the Pittsburgh ...

This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer. While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms ...