A study reveals that the APOE3-R136S mutation delays Alzheimer’s disease by inhibiting the cGAS-STING immune pathway. This mutation suppresses inflammation in brain-resident immune cells, offering ...

The spliceosome is a complex ribonucleoprotein machine that is responsible for the maturation of cellular pre-mRNAs by removing introns and ligating together the surrounding coding regions, called ...

Some doctors told him he'd live with the disease forever, but Khaled Alsheebani never stopped believing treatments would advance one day.

The Emerton family didn't know the odds were always stacked against them, all because of a rare gene. Already, that gene has sent both Clay Emerton and his son, Andrew, into cardiac arrest ...

A rare gene mutation that delays Alzheimer's disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill ...

imageimageDisrupting the expression of the minor spliceosome component RNPC3 reduces the growth of oncogene-driven cancer cells in a broad spectrum of tumours. Targeting the minor spliceosome may ...

Spain's SpliceBio has raised $135m in financing that will help it move a gene-editing therapy for Stargardt disease through clinical testing.