Spliceosome mutations represent a new generation of acquired genetic alterations that affect both myeloid and lymphoid malignancies. A substantial proportion of patients with myelodysplastic ...

During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, removes certain segments. The outcome varies depending on which parts are cut out, resulting ...

The study, led by Goethe University Frankfurt, sheds light on how specific mutations may lead to the retinal disease retinitis pigmentosa. Importantly, these findings could also open the door to ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules that orchestrate the RNA editing process, ... for example those targeting mutations in DNA, ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, ... for example those targeting mutations in DNA, ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

RNA-sequencing has become a cornerstone in the study of gene expression, offering insights beyond mere mRNA transcript abundances. One area of increasing interest is alternative splicing, a ...

Mutations in this gene were found to be associated with a syndrome with symptoms that include intellectual disability, seizures, short stature, neurodevelopmental delay, drooling, motor delay ...

Scientists publish the first detailed blueprint of the human spliceosome, shedding light on gene regulation mechanisms. ... The finding is promising because traditional therapies, for example those ...

Spliceosome assembly in yeast extracts also could occur by interaction of the U1 snRNP with the pre-mRNA, followed by a tetra-snRNP joining to form a functionally identical particle. (Reprinted with ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, ... for example those targeting mutations in DNA, ...