Researchers have identified mutations in the non-coding gene RNU2-2 as a cause of a newly defined neurodevelopmental disorder ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

A major goal of our laboratory is to delineate: • How common oncogenic drivers, such as the transcription factor c-MYC and spliceosome mutations, confer vulnerabilities across multiple levels of RNA ...

It is associated with a particular region of the spliceosome, which is made up of three subunits called U4/U6.U5. We already knew that certain mutations in these subunits are linked to the eye ...