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The spliceosome catalyzes nuclear pre-mRNA splicing via formation of an intron lariat and is arguably the most complex macromolecular machine in eukaryotic cells. Intron lariat formation is a ...

They discovered that malfunctions in the spliceosome, a protein complex responsible for gene splicing, are a key factor in these disorders. This research paves the way for potential therapeutic ...

Spliceosomes, which are the largest and most complex nanomachines that process genetic information, require numerous helicases to regulate their function. Using cryo-EM of stalled spliceosome and ...

Using cryo-EM of stalled spliceosome and biochemical methods, we found that human spliceosomes need to be remodelled by two helicases – PRP2 and Aquarius, ... Prp19 is a homotetramer complex that ...

The formation of large and nuclear oligomeric forms is another possible explanation observed as a consequence of mutated tau. Mutant P301L tau shows a distinct aggregation mechanism compared to WT ( ...

The variable way that the spliceosome combines the nonintron RNA results in about 10 times as many proteins in human cells as the number of genes in our genome. Now, thanks to cryo-electron microscopy ...

Intron removal by the spliceosome is an essential step in precursor messenger RNA (pre-mRNA) processing during eukaryotic gene expression. The spliceosome is composed of a number of subunits including ...

Thank you for submitting your article "Dynamics and Consequences of Spliceosome E Complex Formation" for consideration by eLife.Your article has been favorably evaluated by Michael Marletta (Senior ...

A hPrp28 mutant stalls spliceosome assembly before complex B. To dissect the role of the DEAD-box protein hPrp28 during human spliceosomal B complex formation, we first assayed the effect of an ...