We found that >90% of viral circRNA species lacked canonical splice donor–acceptor sites. Hotspots of viral back splicing were subsequently found refractory to inhibition of the spliceosome or lariat ...

Having found an enzyme, AetD, involved in that pathway that synthesizes a nitrile group—which is uncommon in nature—Moore’s team went on to examine public datasets for related enzymes (Nat ...

This enzyme design process does have some limitations. Serine hydrolases and ester hydrolysis were chosen as the enzyme class and reaction, respectively, because they are very well characterized.

AI used to design a multi-step enzyme that can digest some plastics Enzyme mechanisms can be complex, and getting them to work is tricky. John Timmer – Feb 14, 2025 11:47 am ...

Enzymes are molecular machines that carry out the chemical reactions that sustain all life, an ability that has captured the attention of scientists like me.. Consider muscle movement.

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

“Enzyme engineering is limited by the challenge of rapidly generating and using large datasets of sequence-function relationships for predictive design,” the researchers wrote.

Their work revealed that different components of the spliceosome have unique regulatory functions. Crucially, they found that proteins within the spliceosome’s core are not just idle support workers ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona, a BIST Community centre, have created the first blueprint of the human spliceosome, the most complex and intricate molecular ...

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA ...

Digestive enzymes, for instance, belong to the hydrolase category and help break down foods to make them more easily absorbed throughout the body. There's also metabolic enzymes, which belong to ...