Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

“However, analyzing the components flexibly bound to the periphery of the spliceosome was a major challenge for our work,” explains Dr Komal Soni from the BZH. Based on this structural ...

The fit between a splice site and the spliceosome components that bind it influences splicing activity. Strong splice sites closely match consensus sequences and are efficiently recognized by the ...