Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, but until now, the specific roles of its numerous components were ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules that orchestrate the RNA editing process, but until now, the specific roles of its numerous components were ...

The two first major components of the spliceosome do not need to communicate with one another to start the splicing process, nor does it matter which piece attaches to the gene first. Either of the ...

"However, analyzing the components flexibly bound to the periphery of the spliceosome was a major challenge for our work," ...

Its action essentially induces the movement and hence regulate the function of all the other spliceosome components, namely an enormous machinery composed of more than 100 proteins and 5 filaments ...

A number of compounds, derived from bacterial fermentation products, have been found to target subunits of the spliceosome and display anticancer properties. In this Review, Valcárcel and ...

Spliceosome components may therefore be potential therapeutic targets for MYC-driven cancers. MYC (also known as c-MYC) overexpression or hyperactivation is one of the most common drivers of ...

WATERTOWN, Mass., Oct. 31, 2024 /PRNewswire/ -- Remix Therapeutics (Remix), a clinical-stage biotechnology company developing small molecule therapies to modulate RNA processing and address ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, but until now, the specific roles of its numerous components were ...

Remix Therapeutics (Remix), a clinical-stage biotechnology company developing small molecule therapies to modulate RNA processing and address underlying drivers of disease, today announced the ...