Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

They succeeded once they were able to isolate the splicing complexes of the fungus that were in the midst of quality control ...

Proper splicing requires efficient spliceosome assembly. Here the authors reveal that zinc finger protein 207 interacts with the U1 small nuclear ribonucleoprotein to accelerate spliceosome ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to a handful of model organisms. New research by Lu et al, looks outside this ...

Department of Biophysics, School of Basic Medical Sciences, Health Science Centre, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China The Second Affiliated Hospital, Health Science Centre, Xi’an ...

In addition, it was shown that insulin influences the function of the so-called spliceosome complex, a key regulatory element of gene regulation. This suggests that the hormone insulin performs ...

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Doctorado en Fisicoquímica Molecular, Universidad Andres Bello, República 275, Santiago 8370146, Chile Departamento de Ciencias Químicas (DCQ), Universidad Andres Bello, República 275, Santiago ...

Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read “snurps”) – ...

This knowledge gap can be attributed to the limited availability of protein-RNA structures along with the experimental difficulties in studying these complexes. Recent progress in computational ...