The spliceosome is critical for the proper functioning of every cell, and numerous genetic disorders are linked to problems with spliceosome function. In most eukaryotic cells, two types of ...

"This has been a challenging project, and we're making progress along the way, which is encouraging, but there's still so much to know about the minor spliceosome," said Zhao, who was awarded a Marie ...

The spliceosome is critical for the proper functioning of every cell, and numerous genetic disorders are linked to problems with spliceosome function. In most eukaryotic cells, two types of ...

Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications.

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

The spliceosome is critical for the proper functioning of every cell, and numerous genetic disorders are linked to problems with spliceosome function.

A new process that is essential to the synthesis of cellular proteins has been discovered by an international research team.

The spliceosome itself is composed of 150 different proteins, plus five small RNA molecules. In this study, the researchers examined the activity of 305 human genes that are related to the spliceosome ...

The precise topological arrangement of snRNP complexes involved in spliceosome assembly occurring after initial splice site recognition, determines their activities in splice site selection, ...

Detailed map of the spliceosome is being made publicly available to help researchers pinpoint exactly where splicing errors are occurring in a patient's cells.

Plants have a sophisticated mechanism for monitoring the production of new proteins. The U1 snRNP complex ensures that the protein blueprints are fully completed. This is important because cells tend ...