Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

“And whenever a mistake occurs during splicing, you will find a disease as a result,” added Kevin Chung, a graduate student in the Pyle lab and co-author. Aberrant splicing of mRNA has been implicated ...

Splicing of a pre-mRNA molecule occurs in several steps that are catalyzed by small nuclear ribonucleoproteins (snRNPs). After the U1 snRNP binds to the 5′ splice site, the 5′ end of the ...

Pre-mRNA splicing is a fundamental step in mRNA maturation and its discovery in 1977 revolutionized our understanding of gene expression. This collection includes reviews and research articles ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor, new research finds. Share: Facebook Twitter Pinterest LinkedIN Email.

RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions ...

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

Alternative splicing enables a single gene to encode multiple mRNA variants and, consequently, diversifies protein isoform products. The advent of deep sequencing technologies has revealed that 95 ...

What Is RNA Splicing?RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains ...

What remained unclear, however, was whether the spliceosome can recognize and reject a precursor mRNA with a non-authentic splice site,” explains Prof. Hurt. In studies with spliceosomes of the ...

My lab studies mRNA splicing mechanisms, its dysregulation in cancer and genetic diseases, and the development of RNA-targeted therapeutics.