RNA splicing is a modification of the nascent ... and associated proteins, but there are also self-splicing introns. Spliceosomal snRNP core assembly typically requires chaperones such as the ...

Rgenta Therapeutics, a clinical-stage biotechnology company pioneering the development of a new class of oral small molecules ...

This process, called alternative RNA splicing, fine-tunes how proteins function ... Think of it as a self-destruct button ...

RGT-61159 is an orally available small molecule designed to specifically modulate splicing of the transcription ... regulator of cell proliferation, self-renewal, and differentiation processes ...

Scientists found that pseudouridine helps small RNAs pass on traits and avoid immune detection, offering clues for future RNA ...

Scientists at Oak Ridge National Laboratory have developed the first-ever method of detecting ribonucleic acid, or RNA, ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

We might ask what kind of life is possible for someone after such self-destructive behavior. How can he move ahead knowing the harm he caused? He cannot reclaim the family he lost nor end the ...

The approach is to develop small-molecule drugs that can correct RNA mis-splicing, leading to loss of RNA expression by exon-skipping. It is another way to go after hard-to-target disease ...