Splicing is catalyzed by a large molecular machine. This spliceosome is made up of variety of protein and RNA components, and for each splicing process, it is reassembled at the sites where an ...

Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome ...

With this innovation, the algorithm for searching for new proteins rapidly reduced its computational complexity, becoming non-linear through the spliceosome and the nucleus, which separated ...

This transcript is altered during splicing when specific portions are eliminated by the spliceosome, a cellular editing complex. This results in different blueprints for different proteins ...

Although HPVs do express some unspliced mRNAs (Figure 2), most HPV mRNAs are the products of constitutive and alternative splicing. Constitutive splicing is where every intron in the primary RNA ...

With these funds the Company will focus on investing in its novel spliceosome inhibitor payl On-demand video webcast now available here BOSTON and LONDON, Feb. 19, 2025 (GLOBE NEWSWIRE ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...