Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...

Targeting the G-loop mechanism could be a smart way to hit cancer cells where they’re weak. For example, by increasing the number of G4 knots or blocking their repair, cancer cells could be ...

The circadian clock allows organisms to accurately predict the earth’s rotation and modify their behavior as a result. Genetic analyses in a variety of organisms have defined a mechanism based largely ...

The third luminal loop contains four cysteine residues close to the channel pore. We focused on these four cysteine residues in the ER luminal site to elucidate the molecular mechanism of ...

In the present study, researchers hypothesize a novel mechanism of insulin resistance termed ‘chain-splitting.’ The hypothesis posits that the degradation of endogenous insulin during its ...

It is therefore possible that redox regulation of disulfide bridges may be a widespread mechanism for controlling protein kinase activity and signaling. In a previous study led by Kannan, roughly 10% ...

Impact of T-Loop and CPE Cys-to-Ala mutations on BRSK redox sensitivity in a cellular EGFP-Tau HEK-293T co-expression system. Representative immunoblot of EGFP-Tau co-expressed with WT and Cys-to-Ala ...

The research group discovered the phenomenon of insulin resistance-like "Redox-stress Response Resistance (RRR)" in senescent cells, and revealed a new mechanism of PRDX2 hyperoxidation leading to ...

Cellular stress, or oxidative stress, occurs when there is a buildup of reactive oxygen species (ROS), which interferes with cellular mechanisms and can even cause damage to proteins, lipids, and DNA.

Much is known about the redox-dependent activation of NRF2 and its subsequent role in stress response.In this pathway, Kelch-like ECH-associated protein 1 (KEAP1) senses oxidative stress in the ...