Cysteine disulfides, which constitute an important component in biological redox buffer systems, are highly reactive toward the hydroxyl radical (• OH). The mechanistic details of this reaction, ...

Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...

The reduction of a redox-active ligand is shown to drive reversible switching of a Cu (I) [2]pseudorotaxane ([2]PR+) into the reduced [3]pseudorotaxane ([3]PR+) by a bimolecular mechanism. The ...

The discovery of the G-loop mechanism answers key scientific questions on how cells protect their DNA and could also open doors for future therapies. Many cancers are linked to problems in DNA repair.

Kang, Q. and Yang, C. (2020) Oxidative Stress and Diabetic Retinopathy Molecular Mechanisms, Pathogenetic Role and Therapeutic Implications. Redox Biology, 37, Article ID 101799.

Targeting the G-loop mechanism could be a smart way to hit cancer cells where they’re weak. For example, by increasing the number of G4 knots or blocking their repair, cancer cells could be ...

Tremendous efforts have been devoted to developing chemodynamic cancer therapy (CDT) platforms targeting intracellular antioxidant defense systems to realize an enhanced efficacy. However, such a ...