Biochemists Uncover How Cells Eliminate RNA Splicing Errors
Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...
Fluorescent biosensor tracks plant RNA in real time for better crops and biosecurity
Scientists at Oak Ridge National Laboratory have developed the first-ever method of detecting ribonucleic acid, or RNA, ...
eLife16d
Generative modeling for RNA splicing predictions and design
as it offers both a refined predictive model and a new tool to designing RNA sequences for targeted splicing outcomes. Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific ...
eLife16d
Generative modeling for RNA splicing predictions and design
The authors propose a transformer-based model for the prediction of condition - or tissue-specific alternative splicing and demonstrate its utility in the design of RNAs with desired splicing outcomes ...
Frontiers18d
Identified five variants in CFTR gene that alter RNA splicing by minigene assay
Emerging evidence suggests that some variants, which are described as missense, synonymous or nonsense variants in the literature or databases, may be deleterious by affecting the pre-mRNA splicing ...
C&EN25d
Phosphorylation-Induced Self-Coacervation versus RNA-Assisted Complex Coacervation of Tau Proteins
Institute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan Institute of Biochemical Sciences, National Taiwan ...
gut.bmj1mon
A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma
In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. Design By utilising large scale ...
Frontiers6y
Computational Tools for Splicing Defect Prediction in Breast/Ovarian Cancer Genes: How Efficient Are They at Predicting RNA Alterations?
Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically ...