Nutrition scientists have been working to understand the relationship between type 2 diabetes and genes that express a ...

Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the ...

The new study, funded in part by the National Institutes of Health and published June 18 in Cell Chemical Biology, showed that targeting a key process of how cells make proteins can inhibit cancer ...

Here, we used Single-Molecule Footprinting to measure RNA Polymerase II (Pol II) occupancy, the fraction of DNA molecules bound, at promoters in mouse and Drosophila cell lines. Single-molecule data ...

Le Martelot G, Canella D, Symul L, Migliavacca E, Gilardi F, Liechti R, Martin O, Harshman K, Delorenzi M, Desvergne B, et al. Genome-wide RNA polymerase II profiles and RNA accumulation reveal ...

SAN DIEGO-- (BUSINESS WIRE)-- TriLink BioTechnologies and Alphazyme, both part of Maravai LifeSciences, have collaborated to launch CleanScribe™ RNA Polymerase, a novel enzyme that reduces ...

The RNA polymerase II (Pol II) elongation rate influences poly (A) site selection, with slow and fast Pol II derivatives causing upstream and downstream shifts, respectively, in poly (A) site ...

RNA polymerase II 3 transcribes protein-coding genes into messenger RNA (mRNA). This 12-subunit enzyme works as a complex that directly influences gene expression through its production of pre-mRNA ...

The C-terminal domain (CTD) of RNA polymerase II (Pol II) is a low complexity domain that contains heptapeptide (YSPTSPS) repeating sequence, with the number of repeating units differing according to ...

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor with a poor prognosis. The growth of GBM cells depends on the core transcriptional apparatus, thus rendering RNA polymerase ...

Along with the 10 catalytic subunits found in all RNAPs, RNAP II has two Rpb4⧸7 which initiation transcription. RNAP II is the enzyme primarily responsible for the synthesis of messenger RNA (mRNA).

Transcription by RNA Polymerase II (Pol II) is initiated by the hierarchical assembly of the pre-initiation complex onto promoter DNA. Decades of research have shown that the TATA-box binding protein ...