More information: Komal Soni et al, Structures of aberrant spliceosome intermediates on their way to disassembly, Nature Structural & Molecular Biology (2025). DOI: 10.1038/s41594-024-01480-7 ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps")—and about 150 proteins, involved in different stages of ...

Heidelberg University. "Spliceosome: How cells avoid errors when manufacturing mRNA." ScienceDaily. ScienceDaily, 7 February 2025. <www.sciencedaily.com / releases / 2025 / 02 / 250207122612.htm>.

First blueprint of the human spliceosome revealed Researchers detail the inner workings of the most complex and intricate molecular machine in human biology Date: November 1, 2024 Source: Center ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes – more than nine in ten ...