A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

Reactivation of the cyclin-dependent kinase inhibitor gene p15 in myelodysplastic syndromes and leukemias, which is silenced by promoter methylation, has been observed. 91 Although epigenetic ...

Therefore, promoters are "invisible" when only the exomes of cells are sequenced, as has been commonplace in cancer genetics research. "Promoters are important in determining when specific genes ...

Therefore, promoters are "invisible" when only the exomes of cells are sequenced, as has been commonplace in cancer genetics research. "Promoters are important in determining when specific genes ...

Two promoter regions "face" each other, both of which initiate transcription. This so-called convergent transcription resembles a genomic ghost ride and was long considered an obstacle to gene ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.

Promoter sequences are DNA sequences that define where transcription of a gene by RNA polymerase begins. Promoter sequences are typically located directly upstream or at the 5' end of the ...

Characterizing gene promoters and promoter–terminator combinations is crucial for maximizing the benefits of bioengineering applications in plants. However, traditional methods of identifying ...

Decoding plant gene expression: A deep dive into promoters and terminators for advanced bioengineering. In high-precision bioengineering and synthetic biology, the fine-tuning of gene expression ...