Abbreviations YHJD, Yiqi Huayu Jiedu Decoction; CRC, colorectal cancer; TME, tumor microenvironment; FBS, fetal bovine serum; HE, Hematoxylin-eosin staining; PolyA, polyadenylate; GO, Gene Ontology; ...

For the first time in the world: a team of researchers from Tel Aviv University and the Israel Institute for Biological Research have developed an mRNA-based vaccine that is 100% effective against ...

Presumably the polyadenylate tail is derived from the original genomic polyadenylate tail. The primary enzyme that adds polyadenylates to nascent cellular messenger RNAs is found in the nucleus.

CircRNAs constitute a new class of endogenous regulatory RNAs exhibiting covalently closed continuous ring structures, no 5’ to 3’ polarity and polyadenylate tails. Because circRNAs lack free ends, ...

Graphical Abstract Rationale: NAA15 (N-alpha-acetyltransferase 15) is a component of the NatA (N-terminal acetyltransferase complex). The mechanism by which NAA15 haploinsufficiency causes congenital ...

Genetic cause OPMD is caused by mutations in the PABPN1 gene, which contains the instructions for making the polyadenylate binding protein (PABPN1). The gene is located on chromosome 14, which is ...

ATRC-101 binds to a target that is a ribonucleoprotein (RNP) complex containing polyadenylate-binding protein 1 (PABP-1) bound to poly (A)RNA. Whereas both PABP-1 and poly (A)RNA are ubiquitously ...

The CRISPR system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic elements. When viral RNA transcripts are detected, type III systems adopt an ...

This complex leads to the cleavage of the 3′ end of the histone transcript producing the only known cellular metazoan mRNAs to lack polyadenylate tails. The resultant abundant transcripts will align ...