The cell-surface glycoprotein CD44 is involved in a multitude ... and HA-dependent functions of CD44 in the pathophysiology of various diseases. In addition, the review discusses various strategies ...

Different tumour types metastasize to distinct secondary organs, reflecting the influence of: the malignant cell of origin, aggressiveness of the primary tumour, the direction of circulation ...

Cell death has been implicated in the pathogenesis of multiple forms of heart disease such as myocardial infarction, myocarditis, cardiomyopathy, drug-induced cardiotoxicity, and heart failure of ...

Stem cells can be unipotent, multipotent, pluripotent or totipotent, depending on the number of cell types to which they can give rise. We show that hematopoiesis in a mouse model of VEXAS ...

5 State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Objectives Oesophageal ...

As the majority of patients with hepatocellular carcinoma (HCC) exhibits primary or acquired resistance to antiprogrammed cell death (ligand)-1 (anti-PD-[L]1) therapies, we aimed to investigate the ...

Apr. 4, 2025 — New research shows how small shifts in the molecular makeup of a virus can profoundly alter its fate. These shifts could turn a deadly pathogen into ...

Background The Ehlers-Danlos syndromes (EDS) are heritable disorders of connective tissue (HDCT), reclassified in the 2017 nosology into 13 subtypes. The genetic basis for hypermobile Ehlers-Danlos ...