Opera Theatre plans to build a new performing arts center at the site, at Maryland Avenue and Topton Way off Interstate 170, ...

A St. Louis hospital's suspected permanent closure was confirmed by the state's health agency Tuesday morning.

Tenants are surrendering office space in downtown St. Louis, but developers say there’s still demand for something “new, ...

The soccer training facility "uses a mix of proprietary training methods and advanced third-party technology to enhance ...

A new invasive tick species was recently found in St. Louis County, with more sightings expected this spring and summer.

Washington University School of Medicine in St. Louis has completed a six-floor vertical expansion on the Steven & Susan ...

ST. LOUIS — Temperatures warmed up into the 60s Sunday after a much-needed, widespread rain. Many of us got over 1" of rain, with some localized 3"+ totals. Sunday's rain helps pause the ...

Smallcakes Cupcakery & Creamery opened its newest location Thursday at 2955 Highway K in O’Fallon, Missouri, the chain said ...

With a historic neighborhood renowned for its Italian cuisine, The Hill, it's no surprise that Missouri's best Italian food ...

Washington University School of Medicine completed an expansion of the Steven & Susan Lipstein BJC Institute of Health building in St. Louis.

Watch live news from St. Louis on 5 On Your Side. Stay up to date on what's happening in your community with a 24/7 live stream and on demand content from 5 On Your Side 5+ features the latest ...

Situated about halfway between Kansas City, Missouri, and Indianapolis, St. Louis overlooks the Mississippi River on the Missouri-Illinois border. Inside its 79 neighborhoods, visitors will find ...