However, around 0.5% of introns belong to another class - the minor introns - which are processed by the minor spliceosome. "These minor introns are very rare but extremely critical because they are ...

Its long-separated twin – the minor spliceosome, is much more scarce and remains enigmatic, even though its function is equally important. In this new study, the researchers reveal the structure of ...

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

However, around 0.5% of introns belong to another class – the minor introns – which are processed by the minor spliceosome. “These minor introns are very rare but extremely critical because they are ...

The minor spliceosome has a similar architecture, but its main building blocks are different (U11, U12, U4atac, U6atac, and U5 snRNPs).

The minor spliceosome has a similar architecture, but its main building blocks are different (U11, U12, U4atac, U6atac, and U5 snRNPs).

The research article, titled "Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome," represents a significant advancement in understanding the ...

In their investigations, the team found various indications for the central role of the minor spliceosome in cancer. “We were able to show that a specific component of the minor spliceosome is ...

The evolutionarily conserved minor spliceosome (MiS) is required for protein expression of ∼714 minor intron-containing genes (MIGs) crucial for cell-cycle regulation, DNA repair, and MAP-kinase ...

June 11, 2023 Highlights Increased minor spliceosome activity is associated with prostate cancer progression Minor intron-containing genes are overrepresented as direct interactors with oncogenes ...

The researchers found that a specific component of the minor spliceosome is significantly increased in advanced prostate cancer, leading them to believe that cancer cells stimulate uncontrolled ...