Haber Gazetesi6d
How the World's Best Clinics Achieve Success in Parkinson's Treatment
The world's best clinics achieve success in Parkinson’s treatment by individualizing deep brain stimulation (DBS) through ...
Denali Therapeutics: Vast Pipeline, First Approval Up Ahead
Despite past failures, Denali's extensive pipeline and solid financial runway make it a compelling buy at current low stock ...
Medscape21d
Clinical Management of Intra-Amniotic Infection and Chorioamnionitis: A Review of the Literature
Intra-amniotic infection (IAI), or chorioamnionitis, complicates up to 10% of all pregnancies and up to 2% of labors at term. There is a significant risk of complications for the mother and the ...
C&EN27d
Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor
Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, Rome 00185, Italy ...
C&EN28d
Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors
Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan ...
News Medical1mon
New insights into coumarin-based MAO inhibitors for neurodegenerative diseases
Understanding the structure-activity relationship (SAR) and mechanisms underlying MAO inhibitors is crucial but ... significantly enhanced MAO-B inhibition and increased selectivity for MAO ...
EurekAlert!1mon
Coumarin derivatives as inhibitors against monoamine oxidase: Structure-activity relationships and inhibitory mechanisms
Understanding the structure-activity relationship (SAR) and mechanisms underlying MAO inhibitors is crucial but ... significantly enhanced MAO-B inhibition and increased selectivity for MAO ...
Nature3mon
Endolysosomal proteases and their inhibitors in immunity
Release of proteases from LROs into the host cell cytoplasm can trigger apoptosis unless the proteases are countered by cytoplasmic protease inhibitors. Regulated release of endolysosomal ...