Fintel on MSN2d
Leerink Partners Initiates Coverage of Nurix Therapeutics (NRIX) with Market Perform Recommendation
Fintel reports that on March 17, 2025, Leerink Partners initiated coverage of Nurix Therapeutics (NasdaqGM:NRIX) with a ...
pharmaphorum6d
Astellas extends protein degrader drive with Cullgen deal
ligands for E3 ligases, enzymes involved in the control of protein levels in cells. San Diego, California-based Cullgen – led by Shanghai Genomics' founder, Ying Luo – says the discovery ...
Nature5d
Ubiquitylation articles from across Nature Portfolio
Ubiquitylation is the post-translational modification process by which ubiquitin is attached via an isopeptide bond to lysine residues on a protein. Ubiquitylation consists of three steps ...
eLife6d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
Medscape2d
Glucose Toxicity in Beta-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection
Support for this hypothesis is found in the observations that high glucose concentrations increase intraislet peroxide levels, that islets contain very low levels of antioxidant enzyme activities ...