Nuvectis Pharma, Inc. (NASDAQ: NVCT) ("Nuvectis" or the "Company"), a clinical-stage biopharmaceutical company focused on the ...

"The catalytic mechanism of action and event driven pharmacology triggering ... Nurix's wholly owned, clinical stage pipeline ...

Bexobrutideg, a first-in-class Bruton’s tyrosine kinase degrader, has been granted orphan drug designation from the FDA in ...

Bexobrutideg, a bioavailable agent, was granted orphan drug designation by the FDA for Waldenström macroglobulinemia, a type ...

including DNA repair proteins encoded by the protein kinase, DNA-activated, catalytic subunit gene (PRKDC) and antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT). Experimental ...

NXP900's unique mechanism of action enables the inhibition of both the catalytic and scaffolding functions of the SRC kinase thereby providing complete shutdown of the signaling pathway. NXP900 is ...

This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...

Abl1, a nonreceptor tyrosine kinase closely related to Src kinase ... was reached with the experimentally determined catalytic rates. We conclude that the catalytic mechanism in Abl1 requires one ...

What researchers know about the structure of GRKs has advanced significantly over the past two decades, revealing the intricate mechanisms ... The kinase domain—the Pac-Man—is the catalytic ...

NXP900's unique mechanism of action enables the inhibition of both the catalytic and scaffolding functions of the SRC kinase thereby providing complete shutdown of the signaling pathway.

Q4 2024 Earnings Call Transcript March 20, 2025 Monte Rosa Therapeutics, Inc. beats earnings expectations. Reported EPS is $0 ...

Glycogen phosphorylase kinase (PhK) initiates glycogen degradation ... Here the authors provide evidence that such enzymes utilize a catalytic pentad mechanism that allows for regulation of ...