Nuvectis Pharma, Inc. (NASDAQ: NVCT) ("Nuvectis" or the "Company"), a clinical-stage biopharmaceutical company focused on the ...

including DNA repair proteins encoded by the protein kinase, DNA-activated, catalytic subunit gene (PRKDC) and antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT). Experimental ...

This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...

Glycogen phosphorylase kinase (PhK) initiates glycogen degradation ... Here the authors provide evidence that such enzymes utilize a catalytic pentad mechanism that allows for regulation of ...

Delve into the kinase inhibitors' diverse landscape, from cancer breakthroughs to autoimmune disease innovations.

Life has evolved over billions of years, adapting to the changing environment. Similarly, enzymes—proteins that speed up ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

we hypothesize that chronic oxidative stress is an important mechanism for glucose toxicity. Support for this hypothesis is found in the observations that high glucose concentrations increase ...

is an atypical kinase highly expressed in human and murine hearts. Biallelic loss‐of‐function mutations in ALPK3 lead to pediatric cardiomyopathy. The specific stages at which ALPK3 is essential for ...