the 3′ end of the intron is brought into proximity, cut, and joined to the 5′ end. This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon attacks the ph ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

The vast majority of introns are removed by the major spliceosome ... 3'-OH of the upstream exon attacks the 3' splice site phosphodiester to liberate the lariat intron and join (ligate) the ...

Surprisingly, when spliceosome components were depleted or ... We propose that this is because cross-exon interactions are not easily replaced with cross-intron interactions, thereby causing ...

Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing production of certain messenger RNAs and appear to help cells respond to ...

The spliceosome (not shown) was known to catalyze two chemical reactions (black arrows) in a two-step process (green arrows labeled 1 and 2) that splice the exons together and removes the intron ...