Splicing starts with the recognition of specific sequences at the exon-intron boundaries by the spliceosome. Alternative splicing additionally involves cis-acting regulatory sequences, that, through ...

Surprisingly, when spliceosome components were depleted or ... We propose that this is because cross-exon interactions are not easily replaced with cross-intron interactions, thereby causing ...

Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

exon 6 was skipped. The other mutation is a thymine insertion at the +3 position of the intron 1 donor-splice site. RT-PCR and sequencing revealed a small amount of normal-size mRNA with normal ...

Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...